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Povećan je rizik od sedacije i respiratorne depresije. Poznato je da fenobarbital indukuje CYP3A4 enzim i ubrzava metabolizam diazepama u jetri, što smanjuje efekat diazepama.The FDA restricts utilization of tramadol in youngsters as a result of critical threat of slowed or difficult breathing and death, which look like a better threat in childre

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